Charlie,
We have 2 units on our 400 MKII. They are Cruisair self contained. One is under the V berth on the starbard side. It cools the V berth, forward head and the main salon. The return duct is located under the V berth in the walkway and the cooling duct is run under the V berth, through the port hanging locker. There is a T with the large vent going into the main salon and a smaller going to the V berth. There is also a small vent to the forward head.
The aft unit is located in the top of the port hanging locker and cools just the aft room. Unfortinately I don't recall the size of the units but if you go to the Cruisair site it gives info re sizing.
www.cruisair.com/sheets/L-0854A.pdf
One other factor to take into account is where you live. Down here on the Gulf Coast during the summer, we need all the cooling we can get as it gets pretty hot. If your in the northern climes you probably don't need as much.
Good luck.